screw up:

1. Or: screw , to botch or mishandle, to ruin, spoil, or mess up something, to fail dismally.

Quotes:

(1) Sally (Liza Minnelli) in Cabaret (1972): ' Sex always screws up a friendship anyway .'

(2) Paula McFadden (Marsha Mason) to Elliot Garfield (Richard Dreyfuss) in The Goodbye Girl (1977): ' I love actors, as long as they stay on the stage where they belong. But you put them down in real life and the whole world gets screwed up .'

2. Or: screw-up , a bungler.

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